Our team’s scientific publications

The Science

Published research.

Kunisaki J, et al. (medRxiv 2024)

Sperm from infertile, oligozoospermic men have elevated mutation
rates

Lu X, Luo Y, Nie X, et al. (Nat Commun 2023)

Single-cell Multi-omics Analysis of Human Testicular Germ Cell Tumor Reveals its Molecular Features and Microenvironment

Wamaitha SE, Nie X, et al. (Dev Cell, 2023)

Single-cell analysis of the developing human ovary defines distinct insights into ovarian somatic and germline progenitors

Nie X, et al. (Dev Cell. 2022)

Single-cell analysis of human testis aging and correlation with elevated body mass index

Hickey GJ, et al. (Elife. 2022)

Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

Chen H, et al. (Cell Rep. 2021)

Dissecting mammalian spermatogenesis using spatial transcriptomics

Mahyari E, Guo J, et al. (Am J Hum Genet. 2021)

Comparative single-cell analysis of biopsies clarifies pathogenic mechanisms in Klinefelter syndrome

Guo J, et al. (Cell Stem Cell. 2021)

Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment

Guo J, Nie X, et al. (Cell Stem Cell. 2020)

The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty

Guo J, et al. (Cell Res. 2018)

The adult human testis transcriptional cell atlas

Overcoming male infertility.

Our moral and ethical statement: The founders and leadership of Paterna Biosciences recognize that work with stem cells is considered controversial by some. We can restore fertility using the patient’s own stem cells.

Our position is that we can solve genetic disorders that cause male infertility and beyond. That is our sole focus. We completely reject and will not pursue this work to enable modifications of heritable social traits. We view that as immoral and will have no part in it.

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